Tourette e Alergias

Na prática clínica eu já tinha percebido que as crianças com Tourette tinha e grande frequência doenças alérgicas tais como rinite, bronquite, asma etc. Alguns pacientes meus desenvolveram Púrpura Trombocitopênica que é uma reação a medicamento com baixa das plaquetas e que parece ter origem autoimune.
Dada a frequência da associação entre rinite alérgica e os tiques de nariz (mexer o nariz, fungar etc), atualmente é prática corrente eu tratar a rinite dos pacientes além de tratar os tiques, sendo o resultado muito melhor.
Pois bem, começaram a aparecer estudos que comprovam a associação entre doenças alérgicas e a Tourette:

Eur Rev Med Pharmacol Sci. 2014 Feb;18(3):303-10.

Association of Tourette syndrome and obsessive-compulsive disorder with allergic diseases in children and adolescents: a preliminary study.

Yuce M1, Guner SN, Karabekiroglu K, Baykal S, Kilic M, Sancak R, Karabekiroglu A.

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Abstract

OBJECTIVES:

To investigate the rate of allergic diseases including asthma, allergic rhinitis and eczema in children and adolescents diagnosed with obsessive-compulsive disorder (OCD) (n:26) and/or Tourette syndrome (TS) (n:32) [OCD plus TS, n:13] compared to control subjects (n:35) [total, n:80].

PATIENTS AND METHODS:

The symptoms of any allergic disease were assessed using the ISAAC questionnaire form. Allergy diagnoses were made by a pediatric allergy specialist. Skin prick tests were applied, and IgE levels and eosinophil counts were measured.

RESULTS:

While only one-fifth of the control subjects had allergic diseases, more than half of the children with TS and/or OCD had comorbid allergic diseases. Positive skin prick tests were greater in OCD patients compared to control subjects. There were no significant differences between the groups in terms of eosinophil counts or IgE levels. Among the allergic diseases, while allergic rhinitis was diagnosed at significantly higher rates in TS patients, eczema was significantly higher in OCD patients compared to control subjects.

CONCLUSIONS:

This preliminary study shows an association between allergic diseases and TS and/or OCD. The results revealing differences in associations between types of allergic disease (rhinitis or eczema) and neuropsychiatric disorder (tic disorder or OCD) need to be investigated in further studies with higher numbers of participants, and immune markers should be examined.

PMID:

 

24563428

 

[PubMed - in process] 

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